Monday, August 15, 2005

ONTAK

Reported use of ONTAK to hold T-PLL at bay after failed Campath treatment.


ONTAK

Biologic Response Modifier Agent: Denileukin Diftitox. Denileukin diftitox is a fusion protein (a combination of diphtheria toxin and interleukin-2) which selectively delivers the cell-killing activity of the diphtheria toxin to targeted cells. The lymphoma cells need to be a specific type -- they must express the high affinity IL-2 receptor on the surface of the cancer cell which then permits the IL-2 part of the fusion protein to attach/bind to the cell, halt protein synthesis and lead to cell death because of the diptheria toxin.

5 comments:

Robin said...

Hi,
Are you still blogging.... Do you have any current info on t pll? My mom was recently diagnosed and all the info seems to be 5-10 years old. ThanksW!!

Mark said...

Hi!

Send me an e-mail and let's discuss; I can plug you in with a few others too.

Suzanne said...

Hi..
I too cannot find current info. Do you still blog on this site? I would like to hear from you.
Suzanne

Robin said...

I am happy to blog with anyone about my experiences with my mom going through her T PLL. Unfortunately, this past Saturday is the one year anniversary of her death. As a way to honor her and her memory, I rode in the Seattle to Portland bicycle ride as a fundraiser for the Leukemia/Lymphoma Society. They are a really good organization that I would recommend people hook up with. They don't really know anything about T PLL as it is soooo rare, however, they are great emotional support and can also help out some financially... Something else I found out during the course of helping my mom, if you have any meds you are taking and they cost much, check with each individual drug company to see if they have any assistance programs. My mom needed a drug that cost 1300.00 a month, and we were able to get it from the drug company for 10.00 for a 90 day supply. Thanks all for reading this and my prayers are with everyone...

Mark said...

Dear Robin and Suzanne,

Thank you for posting comments.

please email me at mgross@integrity.com