Reported use of ONTAK to hold T-PLL at bay after failed Campath treatment.
ONTAK
Biologic Response Modifier Agent: Denileukin Diftitox. Denileukin diftitox is a fusion protein (a combination of diphtheria toxin and interleukin-2) which selectively delivers the cell-killing activity of the diphtheria toxin to targeted cells. The lymphoma cells need to be a specific type -- they must express the high affinity IL-2 receptor on the surface of the cancer cell which then permits the IL-2 part of the fusion protein to attach/bind to the cell, halt protein synthesis and lead to cell death because of the diptheria toxin.
T-Cell Prolymphocytic Leukemia (T-PLL) is a very rare and aggressive form of Leukemia, with approx. 10 cases/year in the US. Most Oncologists have never seen a case, and because of this, it is a good idea to learn as much as you can about it. If you have been diagnosed with T-PLL, or are caring for someone diagnosed with it, you are probably pretty "lonely" - but not alone.
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T-PLL Articles
Doctors
- Alan Saven, M.D. (Scripps Clinic, La Jolla, CA)
- Carolyn Collins, M.D. (Mercy Medical, Redding CA)
- Kanti Rai, M.D. (Chief of Hematology-Oncology, Long Island Jewish Medical Center)
- Myron Czuczman, M.D.(Head, Lymphoma/Myeloma Service, Roswell Park Cancer Institute)
- Timothy G. Call, M.D. (Mayo Clinic, Rochester, MN)
Campath Articles
Treatment Articles
Flow Cytometry links
- Wiki page
- Powerpoint lecture slides - FLow Cytometry
- Flow Cytometry at MHMH
- Flow Cytometry Description
- Flow cytometry, confocal microscopy, image analysis, biology education, high school, bioscope, imaging, visualization, cytometr
- CD52 - Jrnl of Bio Regulators etc
- Flow Cytometry Laboratory Now Detecting T-Cell Clonality
