Reported use of ONTAK to hold T-PLL at bay after failed Campath treatment.
ONTAK
Biologic Response Modifier Agent: Denileukin Diftitox. Denileukin diftitox is a fusion protein (a combination of diphtheria toxin and interleukin-2) which selectively delivers the cell-killing activity of the diphtheria toxin to targeted cells. The lymphoma cells need to be a specific type -- they must express the high affinity IL-2 receptor on the surface of the cancer cell which then permits the IL-2 part of the fusion protein to attach/bind to the cell, halt protein synthesis and lead to cell death because of the diptheria toxin.
T-Cell Prolymphocytic Leukemia (T-PLL) is a very rare and aggressive form of Leukemia, with approx. 10 cases/year in the US. Most Oncologists have never seen a case, and because of this, it is a good idea to learn as much as you can about it. If you have been diagnosed with T-PLL, or are caring for someone diagnosed with it, you are probably pretty "lonely" - but not alone.
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T-PLL Articles
Doctors
- Alan Saven, M.D. (Scripps Clinic, La Jolla, CA)
- Carolyn Collins, M.D. (Mercy Medical, Redding CA)
- Kanti Rai, M.D. (Chief of Hematology-Oncology, Long Island Jewish Medical Center)
- Myron Czuczman, M.D.(Head, Lymphoma/Myeloma Service, Roswell Park Cancer Institute)
- Timothy G. Call, M.D. (Mayo Clinic, Rochester, MN)
Campath Articles
Treatment Articles
Flow Cytometry links
- Wiki page
- Powerpoint lecture slides - FLow Cytometry
- Flow Cytometry at MHMH
- Flow Cytometry Description
- Flow cytometry, confocal microscopy, image analysis, biology education, high school, bioscope, imaging, visualization, cytometr
- CD52 - Jrnl of Bio Regulators etc
- Flow Cytometry Laboratory Now Detecting T-Cell Clonality
5 comments:
Hi,
Are you still blogging.... Do you have any current info on t pll? My mom was recently diagnosed and all the info seems to be 5-10 years old. ThanksW!!
Hi!
Send me an e-mail and let's discuss; I can plug you in with a few others too.
Hi..
I too cannot find current info. Do you still blog on this site? I would like to hear from you.
Suzanne
I am happy to blog with anyone about my experiences with my mom going through her T PLL. Unfortunately, this past Saturday is the one year anniversary of her death. As a way to honor her and her memory, I rode in the Seattle to Portland bicycle ride as a fundraiser for the Leukemia/Lymphoma Society. They are a really good organization that I would recommend people hook up with. They don't really know anything about T PLL as it is soooo rare, however, they are great emotional support and can also help out some financially... Something else I found out during the course of helping my mom, if you have any meds you are taking and they cost much, check with each individual drug company to see if they have any assistance programs. My mom needed a drug that cost 1300.00 a month, and we were able to get it from the drug company for 10.00 for a 90 day supply. Thanks all for reading this and my prayers are with everyone...
Dear Robin and Suzanne,
Thank you for posting comments.
please email me at mgross@integrity.com
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